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Nick Norwitz MD PhD

Nick Norwitz MD PhD

MD, Harvard | PhD, Oxford | Motto: StayCurious | Thanks for Learning with Me!About: Dr. Nick Norwitz graduated valedictorian from Dartmouth College, where h...

YouTube2h ago

Heart Rate Variability (And The Coffee that Almost Killed Me)

For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://staycuriousmetabolism.substack.com/p/why-you-need-to-track-your-heart?r=40ekz2 If you want to try the omega supplement I use, Accentrate Omega Max, here’s the link: https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% Off Heart rate variability (HRV) is more than just a number, it’s a real-time window into how well your brain, heart, and nervous system are working together. In this video, we break down what HRV actually measures, why it’s such a powerful predictor of mortality and heart attack risk, and how it reflects something deeper: your body’s ability to adapt, recover, and respond to stress. We walk through landmark studies showing that low HRV is associated with significantly higher risk of death and first cardiac events—even after controlling for traditional risk factors. But this isn’t just about risk. HRV is something you can measure today and actively improve through exercise, nutrition, and targeted breathing strategies. Finally, we tie it all together with a personal story about how a simple cup of coffee (or tea) led to a severe physiological event that highlights just how dynamic and complex the nervous system can be. By the end, you’ll understand not just what HRV is, but how to use it as a practical tool for better health and performance. ⁠Chapters 0:00 – The Coffee that Almost Killed Me 1:30 – Roadmap to this Video 2:07 – Chapter 1: What is Heart Rate Variability (HRV)? 5:30 – Chapter 2: Why Does HRV Matter? 8:57 – Chapter 3: How to Measure and Improve HRV? (Exercise, Caffeine, Omega-3s, Biofeedback) 18:38 – Chapter 4: The Craziest Coffee Story You’ll Ever Hear! #HeartRateVariability #HRV #HealthScience #Longevity #CardiovascularHealth #Biohacking #Wearables #Whoop #OuraRing #FitnessScience #Recovery #StressManagement #NervousSystem #VagusNerve #Omega3 #BreathingTechniques #Zone2 #HIIT #HealthOptimization #StayCurious

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YouTube5d ago

I Tried Retatrutide – Here's What Happened

If the peptide and biohacking world is of interest to you, you need to check out our new Peptides & More library at StayCurious Metabolism: https://staycuriousmetabolism.substack.com/p/peptides It's an absolute treasure trove of information that you won't find elsewhere. Also, if you'd like the written version of this video, with additional details and references, here it is: https://open.substack.com/pub/staycuriousmetabolism/p/i-tried-the-trillion-dollar-weight?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Also, let me be clear: I have NO CONFLICTS OF INTEREST with any pharmaceutical companies. This video is for informational purposes only and does not benefit the pharmaceutical industry in any direct way, shape, or form. Hundred Health Link: https://go.hundred.com/nick-norwitz Discount Code: StayCurious50 for $50 off Pinealon Letter: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2 GLP DXA Letter: https://staycuriousmetabolism.substack.com/p/this-new-study-changed-my-mind-on?r=40ekz2 Heart Rate Variability video: https://youtu.be/bdxYexIpYjo Chapters 0:00 – I Tried the Trillion Dollar Weight Loss Drug. Here’s Why… 2:10 – Part 1, Why Reta Is Different 5:10 – Part 2, The Two Big Reta Paradoxes 7:18 – Part 3, My Personal Experience With Reta 16:54 – Part 4, Resolving the Reta Paradoxes 20:42 – Part 5, The Trillion-Dollar Question… Could retatrutide (Reta) become the most powerful weight-loss drug ever created? In clinical trials, users lost roughly 24% of their body weight, outperforming earlier GLP-1 drugs like Ozempic and even newer agents like tirzepatide. But when I started hearing reports that some people were getting hungrier on retatrutide—and rumors that it might preserve muscle while accelerating fat loss—I decided to investigate for myself. In this video, I break down the science behind retatrutide's unique three-receptor mechanism (GLP-1, GIP, and glucagon), share my personal month-long experiment, and review what happened to my weight, appetite, resting heart rate, body temperature, sleep, cholesterol, inflammation markers, and more. Along the way, we'll explore two major retatrutide paradoxes: why some users report increased hunger despite losing weight, and whether the drug may preserve muscle in certain individuals despite what clinical trials suggest. Finally, we zoom out to discuss a bigger question: are these merely weight-loss drugs, or are they the first generation of targeted bioregulators that could reshape how we think about human health, metabolism, and longevity? As always, we'll follow the evidence wherever it leads… #Retatrutide #GLP1 #GLP1Drugs #Ozempic #Wegovy #Mounjaro #Zepbound #WeightLoss #FatLoss #Metabolism #MetabolicHealth #Longevity #Biohacking #HealthOptimization #Obesity #WeightLossJourney #Fitness #Nutrition #BodyComposition #FGF21 #Glucagon #GIP #Appetite #Hunger #Cholesterol #LDL #ApoB #PCSK9 #HeartRate #HRV #Biomarkers #BloodTesting #Inflammation #hsCRP #SleepHealth #SleepOptimization #Peptides #HealthScience #MedicalScience #ClinicalTrials #PreventiveMedicine #CardiometabolicHealth #HealthyAging #LongevityScience #MetabolicFlexibility #Research #ScienceCommunication #StayCurious #NickNorwitz #Reta

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YouTubeJun 06, 2026

BPC-157 Made This Injured Muscle Grow Back Stronger

Deep dive here: https://staycuriousmetabolism.substack.com/p/bpc-157-bro-science-or-breakthrough BPC-157 is a recovery peptide being studied for its potential effects on tissue healing and repair. In this animal muscle injury model, BPC-157-treated tissue showed better structural recovery, strength, and function compared to untreated tissue. Researchers believe it may work through multiple pathways, including blood flow, growth factor signaling, and tissue repair mechanisms. For the full mechanisms, limitations, and nuance, watch the long-form breakdown linked above. #BPC157 #MuscleRecovery #PeptideTherapy #SportsRecovery #Longevity #GutHealth #StayCurious

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YouTubeJun 05, 2026

Sunlight LooksMaxing (Backed by Science)

For extra nuances and all the references, please see the newsletter: https://staycuriousmetabolism.substack.com/p/how-i-hacked-my-girlfriends-brainwith?r=40ekz2&utm_campaign=post&utm_medium=web&triedRedirect=true Can light influence attraction, hormones, and even reproductive biology? In this video, we explore surprising research on light exposure, testosterone, estrogen, fertility signals, and behavioral changes observed in both animal models and human studies. From hormone cascades triggered through the skin to seasonal changes in reproductive biology, this is a fascinating look at how deeply light may shape human physiology. Along the way, I also test whether increasing my own sunlight exposure changes my testosterone levels and reveal how my girlfriend hacked my brain! For more nuance, mechanisms, protocols, and limitations behind these findings, check out the full deep dive linked above. Chapters 0:00 – Light Can Make You More Attractive 3:00 – The Dance Between Light and Human Evolution 6:37 – Some Crazy Experiments in Mice 9:22 – Human Studies on Attraction & Hormones 11:05 – Nick’s Funny Personal Diamond Necklace Story 12:12 – Fertility & Reproductive Biology 13:51 – The Science of Solar Angle 14:53 – My Sunlight Testosterone Experiment 15:20 – The Bigger Picture of Light & Hormones #Sunlight #Testosterone #UVB #Hormones #Metabolism #Fertility #HealthScience #Longevity #CircadianRhythm #Biohacking #MensHealth #WomensHealth #LightExposure #HumanBiology #Mitochondria #EvolutionaryBiology #HormoneHealth #Phototherapy #Science #StayCurious

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YouTubeJun 04, 2026

⁠Gain Muscle, Lose Fat? The New Biology Behind It

Deep dive here: https://staycuriousmetabolism.substack.com/p/a-breakthrough-in-fat-loss-and-muscle?r=40ekz2&utm_campaign=post&utm_medium=web&triedRedirect=true Researchers are exploring a new approach to body composition by blocking biological signals that normally limit muscle growth. In monkey studies, this strategy reduced fat mass while increasing lean mass, and an early human trial reported gains in lean mass alongside fat loss after a single treatment. While these findings are still early, they could represent an important step forward in metabolic and muscle biology. Deep dive here: https://staycuriousmetabolism.substack.com/p/a-breakthrough-in-fat-loss-and-muscle?r=440ekz2&utm_campaign=post&utm_mediumweb&triedRedirect=true Now see the long-form breakdown linked above. #MuscleGrowth #FatLoss #BodyComposition #MetabolicHealth #Longevity #HealthScience #StayCurious

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YouTubeJun 01, 2026

The Technology That Will Change Humans Forever

For extra nuances and all the references, please see the newsletter: https://staycuriousmetabolism.substack.com/p/can-we-become-like-captain-america?r=40ekz2 The StayCurious Human Enhancement Series We're launching a new series at StayCurious Metabolism called Peptides Plus, where we'll explore the most promising tools available today—and the innovations that may shape tomorrow. We have dozens of deep dives planned, covering everything from emerging therapeutics to cutting-edge performance and longevity interventions. GO HERE: https://staycuriousmetabolism.substack.com/p/peptides Chapters 0:00 — Superhuman Biology Is Already Starting 2:40 — Beyond GLP-1: Fat Loss Without Muscle Loss 7:28 — Gene Editing, CRISPR, and the Future of Disease Cure 14:57 — Cellular Reprogramming and Biological Age Reset 18:49 — MicroRNAs, Mitochondria, and What Comes Next Video Description What if the idea of “superhuman biology” isn’t science fiction anymore—but early-stage reality? From drugs that selectively burn fat while preserving muscle, to gene editing technologies capable of correcting disease at the DNA level, the frontier of human bio-optimization is moving faster than most people realize. In this video, we explore how breakthroughs like myostatin inhibition, CRISPR and prime gene editing, prime editing, and cellular reprogramming are converging toward a future where biology itself can be engineered. Along the way, we examine real clinical data—from 100% fat loss outcomes in trials to gene therapies curing genetic diseases—and unpack what’s actually possible today versus what’s coming next. This is not about unearened hype or pure fantasy. It’s a grounded, evidence-based look at how modern science is beginning to close the gap between comic book imagination and real-world biology—and the implications that come with it. #GeneEditing #CRISPR #HealthScience #FutureOfMedicine #HumanOptimization #AntiAging #Metabolism #MuscleGrowth #FatLoss #Biotech #MedicalInnovation #Superhuman #LongevityScience #Neuroscience #AlzheimersResearch #Genetics #PrecisionMedicine #FitnessScience #HealthOptimization #CellularBiology #Epigenetics #YamanakaFactors #Mitochondria #MicroRNA #Biology #ScienceExplained #MedicalBreakthrough #LongevityResearch #FutureHealth #Bioengineering #HealthTech #WellnessScience #AgingResearch #ClinicalTrials #ObesityTreatment #MuscleScience #MetabolicHealth #ScientificResearch #HumanPerformance #NextGenMedicine #DNAEditing #StemCells #HealthFuture #StayCurious #ScienceContent #MedicalScience #Innovation #BiologyFacts

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YouTubeMay 28, 2026

Scientists Just Gene-Edited Humans to Lower Cholesterol (Really!)

Link: https://open.substack.com/pub/staycuriousmetabolism/p/will-this-gene-editing-breakthrough?r=40ekz2&utm_medium=ios The headline-breaking news this week was that scientists are now gene editing humans to lower LDL. People are calling it one of the biggest cardiology breakthroughs of the century. But people are missing the bigger story. What’s truly fascinating is the technology itself. This therapy uses CRISPR gene editing packaged inside a lipid nanoparticle engineered with a molecular targeting signal that direct it specifically to the liver. Not the brain. Not the heart. Not muscle. Not fat tissue. Just the liver. That level of precision opens the door to something much larger than cholesterol lowering. Because once you can safely and selectively edit specific tissues, you we open to door to preventing a host of chronic diseases, from obesity to diabetes to Alzheimer’s to autoimmune diseases … and you’re potentially talking about upgrading aspects of the human operating system itself. Now, there are still major hurdles ahead, which we discuss in the letter. But this is a very interesting first step. It’s not a cholesterol story — that’s just the proverbial click bait. #LDL #APOB #STAYCURIOUS #PCSK9 #CRISPR #VERVE102

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YouTubeMay 26, 2026

The #1 Nutrient For Brain Health (It's Not Even Close)

For a written breakdown and early access to content, see the letter: https://staycuriousmetabolism.substack.com/p/omega-3-across-the-lifespan-my-1?r=40ekz2 If you want to try the Lyso-DHA omega supplement I use, Accentrate Omega Max, here’s the https://www.fenixhealthscience.com/staycurious Use Discount Code StayCurious for 20% Off LPC-DHA Video: https://youtu.be/B-kEn0FukXM Lithium Video: https://youtu.be/Hcz0Eyp1LE4 NAD Video: https://youtu.be/-R7sPPQTtco Interview with Bill Harris Part 1: https://youtu.be/rZT4Y6T_0Vc Interview with Bill Harris Part 2: https://youtu.be/fdBToTJ0jqs Omega Quant If you want to get your Omega-3 via Omega Quant, click on this link: https://omegaquant.com/ref/864 Discount Code: NickNorwitz for 10% off In this video, I break down the science that matters most if you care about brain health, longevity, and preventing cognitive decline—starting with one molecule that may be more important than anything else: DHA. We’ll walk through how DHA supports your brain structurally, metabolically, and anti-inflammatorily—and why it may be especially critical for people at higher genetic risk. You’ll also learn about one of the earliest changes in Alzheimer’s disease (long before symptoms appear), how lipid metabolism shifts over time, and what that means for prevention. This isn’t about hype—it’s about understanding biology deeply enough to act early. Finally, I’ll share my personal protocol—what I actually do knowing my genetic risk—and how I think about diet, supplements, and lifestyle from a first-principles perspective. If you want to think like a neuroscientist and take control of your brain health, this is for you. Chapters 0:00 – My No 1 Nutrient for Brain Health 1:53 – Roadmap to this video 2:58 – Part 1, Meet DHA 4:33 – Part 2, Big Fat Metabolic Shift 10:59 – Part 3, Biological Mechanisms 14:46 – Part 4, My Personal Protocol #Alzheimers #BrainHealth #DHA #Omega3 #Neuroscience #Longevity #ApoE4 #CognitiveHealth #Memory #NutritionScience #PreventAlzheimers #Biohacking #HealthOptimization #Omega3Benefits #BrainFood #Neurodegeneration #LongevityScience #HealthyAging #Metabolism #Inflammation #BDNF #Neuroprotection #FishOil #Sardines #Nootropics #CognitiveFunction #BrainOptimization #StayCurious #ScienceBased #MedicalScience #FunctionalMedicine #Healthspan #Lifespan #DietAndHealth #BrainNutrition #Neurobiology #MindHealth #BrainRepair #BrainEnergy #Mitochondria #OxidativeStress #WellnessScience #PreventativeHealth #Biohacker #ClinicalResearch #MedicalEducation #ScienceExplained #HealthTips #BrainLongevity #MentalClarity

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YouTubeMay 23, 2026

My Cholesterol Was 700 for 7 Years… Then This Happened

Full video: https://youtu.be/TmloFV0W6iQ Paper: https://www.mdpi.com/2079-9721/14/5/168 For nearly a decade, my LDL cholesterol remained above 500, and my total cholesterol was 700—levels many doctors would consider deadly. Yet an advanced heart scan found zero detectable soft or calcified plaque in my arteries. Here’s a peak and what this could mean. Then, if you’re curious, watch the long-form video linked above. There is no faking this… #Cholesterol #LDL #HeartHealth #CardiovascularHealth #MetabolicHealth #ScienceEducation #StayCurious

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YouTubeMay 18, 2026

I Bet My Life Against Cholesterol Dogma (And Won)

If you appreciate nuanced science and learning about human metabolism, check out StayCurious Metabolism, now a Top Overall Best-Seller in Science globally: https://staycuriousmetabolism.com Start by checking out the Heart Health Archives. Papers: Seven Years of 700 Cholesterol Without Coronary Atherosclerosis: https://www.mdpi.com/2079-9721/14/5/168 Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/ Cholesterol Code Movie: https://cholesterolcodemovie.com Description For seven years, I’ve been living with cholesterol levels that most doctors would say should have killed me by now — not just high, but astronomical — and I did it intentionally because I believe there’s something fundamentally misunderstood about cholesterol, heart disease, and people like me that modern medicine doesn’t understand. If I’m right, the implications could challenge some of the biggest assumptions in cardiology; if I’m wrong, I could end up dead. Today, I finally found out the truth in a way that can’t be faked. This is, without question, the most important video I’ve ever made. Chapters 0:00 – The 7-Year Experiment 1:43 – My Extremely High LDL Cholesterol Should Be Killing Me 2:26 –My Advanced Coronary CT Angiography (CCTA) Heart Scan 5:30 – Interpreting My Heart Scan results 6:30 – What Does This Really Mean for the Patient? 10:00 – Why I Took Bet on My Life and My Heart. 11:15 – What the Critics Will Say 12:15 – The Cholesterol Code Movie 12:50 – The Second Bet and Our Future Together #cholesterol #atherosclerosis #LDL #ApoB # educational #CCTA #LMHR #coronarycalcium #inflammation #metabolicsyndrome #plaqueprogression #arterialhealth #insulinsensitivity #fastinginsulin #hearthealth #ketogenicdiet #metabolicflexibility #lipidprofile #coronaryarterydisease #lipids #heartscan #atherogenic #vascularhealth #metabolichealth #lowcarb #ketoscience #cardiometabolic #cholesterolmyths #insulinresistance #longevity #biomarkers #advancedlipids

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YouTubeMay 14, 2026

The Mitochondrial Hormone Everyone’s Talking About (MOTS-c)

For the written deep dive, see the associated StayCurious Metabolism Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/mots-c-the-mitochondrial-peptide?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Scientists discovered hidden instructions in mitochondria that code for signaling molecules called mitokines, including MOTS-c. In pre-clinical studies, MOTS-c has been linked to increased energy expenditure, improved exercise performance, fat loss, and even lifespan extension in animals, while also increasing naturally during exercise in humans. Some people are now experimenting with injecting it themselves to explore its potential effects. For the full mechanisms, limitations, and nuance, check the deep dive breakdown linked above. #MOTSC #Mitochondria #Longevity #Metabolism #ExerciseScience #HealthyAging #StayCurious

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YouTubeMay 11, 2026

How to Lose Visceral Fat in 8 Weeks (Proven in RCTs)

For all references, extra nuances, and early access to breakdowns like this, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/shrink-visceral-fat-by-feeding-your?r=40ekz2 Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS Use Discount Code “StayCurious” for 15% Off Microplastics and Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Microplastics and Brain Health, Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2 Description: In this video we examine the scientific evidence behind resistant starch, including randomized controlled trials showing reductions in body weight, total fat mass, and visceral fat measured by MRI—even when calorie intake remains controlled. We also explore the biological mechanism, including how changes in the gut microbiome may drive these effects. But there’s an important twist: not everyone responds the same way. We’ll look at new research explaining why some people are “high responders” while others see little benefit, and what role specific gut bacteria play. Finally, we discuss practical ways to experiment with resistant starch yourself—from green bananas to high-amylose maize starch—and how to approach it carefully. Chapters 0:00 – The Strange Science Inside a Green Banana 1:30 – A Roadmap to This Video 3:08 – Chapter 1: What Resistant Starch Actually Is 5:18 – Chapter 2: Human Trials Showing Fat & Visceral Fat Loss 8:17 – Chapter 3: Mechanism of Action: Microbiome & Metabolism 10:17 – Chapter 4: Why Some People Respond and Others Don’t 14:14 – Chapter 5: Practical Ways to Use Resistant Starch 18:04 – Big Picture: Personalized Nutrition & the Microbiome Hashtags #ResistantStarch #GutMicrobiome #GutHealth #MetabolicHealth #VisceralFat #FatLossScience #NutritionResearch #NutritionScience #Microbiome #Microbiota #InsulinSensitivity #WeightLossScience #HealthScience #NutritionFacts #Digestion #GutBacteria #Prebiotics #HealthResearch #Biochemistry #Metabolism #HealthOptimization #GreenBananas #NutritionEducation #ScienceExplained #Healthspan #LongevityScience #DietScience #MicrobiomeResearch #HealthData #BodyFat #VisceralFatReduction #MetabolicFitness #FunctionalNutrition #NutritionTips #HealthyLifestyle #HealthInsights #DigestiveHealth #ScientificResearch #NutritionStudy #ClinicalTrial #NutritionNerd #StayCurious #HealthLearning #NutritionBiology #MicrobiomeHealth #PrebioticFiber #MetabolicScience #ScienceOfHealth #HealthBreakdown #NutritionExplained

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YouTubeMay 09, 2026

The Sardine Diet Gave Me A Superpower ⁠

For the long-form video: https://youtu.be/0a7q8ENyBOk During a month-long sardine experiment, I noticed something bizarre: I stopped feeling cold, even during New England blizzards. Digging into the research led me to omega-3-derived molecules like 12-HEPE, which may increase brown fat activity, heat production, and energy expenditure. Even stranger, the receptor involved is related to smell signaling pathways that appear to influence metabolism throughout the body. For the full mechanisms, limitations, and nuance, watch the long-form video linked above. #Omega3 #BrownFat #Metabolism #Sardines #ColdExposure #MetabolicHealth #StayCurious

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YouTubeMay 07, 2026

This Tiny Peptide Might 2X REM Sleep!

For the written breakdown, early access to information like this, and extra nuances, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/why-im-trying-this-peptide-for-sleep?r=40ekz2 A tiny peptide called Pineolon is gaining attention for its potential effects on REM sleep, brain fog, and sleep quality. Early mechanistic and animal data suggest it may influence melatonin-related pathways, neuroprotection, and even gene expression. While the evidence is still emerging, anecdotal reports from scientists, e.g. Andrew Huberman, and physicians experimenting with it have been fascinating enough to spark deeper investigation. For the full mechanisms, limitations, and nuance, check out the breakdown linked above. #SleepScience #REMsleep #Pineolon #Peptides #BrainHealth #Neuroprotection #StayCurious

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YouTubeMay 06, 2026

The Sardine Diet Gave Me a Superpower (And a Very Unfortunate Side Effect)

For the written breakdown, early access to information like this, and extra nuances, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/why-stinking-like-sardines-might?r=40ekz2 Description I ran an experiment on myself where I ate 1,000 sardines in a month. What followed was something I didn’t expect. Along with a very real (and very noticeable) side effect, I developed what felt like a metabolic “superpower”: extreme cold resistance and increased energy. In this video, I break down the strange physiological changes I experienced and the cutting-edge 2026 science that may explain them. But this isn’t just about sardines. It’s about a deeper principle in biology: everything in the body is connected. When you change one pathway, others move with it. Understanding those connections may be the key to unlocking new ways to optimize metabolism. But as this experiment shows, every benefit comes with a trade-off. Chapters 0:00 – The 1,000 Sardine Experiment 1:50 – Roadmap to this Video 3:52 – Part 1: The Superpower 5:10 – The Omega-3 Heat Hormone (12-HEPE) 7:37 – Part 2: The Breakthrough Study & Smelly Price 9:08 – Part 3: The Connection Between the Power and the Price #sardines #nutrition #metabolism #health #science #diet #omega3 #fatloss #biohacking #fitness #healthscience #nutritiontips #weightloss #wellness #longevity #metabolichealth #keto #lowcarb #fishdiet #superfood #guthealth #hormones #biochemistry #humanbody #scientific #research #clinicalscience #healthtips #fitnessjourney #fatburning #thermogenesis #omega3fattyacids #brainhealth #hearthealth #dietexperiment #selfexperiment #n1experiment #medicalscience #staycurious #foodscience #energy #fatlossjourney #healthyfats #metabolicrate #bodycomposition #nutritionfacts #scienceexplained #biologymatters #coldexposure #performance

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YouTubeMay 01, 2026

I Changed My Mind on Cholesterol Medications (After 7 Years)

For a written breakdown, more nuances and early access to content, see the associated newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/im-finally-lowering-my-cholesterol?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Statin RCT Video: https://youtu.be/d9LeDSoYOVc Ezetimibe Video: https://youtu.be/5idzP5ghT7A Bempedoic Acid Letter: https://staycuriousmetabolism.substack.com/p/beyond-cholesterol-the-unfolding?r=40ekz2 Description For the last seven years, despite extremely high cholesterol, I refused cholesterol-lowering medications. But I’ve just changed my mind…sort of. In this video, I walk through the full decision-making process: the risks, the uncertainty, the medical context, and the nuances that made this case unusually complicated. There are three plot twists. This is not medical advice. It’s a detailed look at an unusual case, and an invitation to stay curious, think critically, and keep an open mind in the face of medical dogma. Chapters 0:00 – My Cholesterol 2:50 – Roadmap for this video 4:10 – Part 1, 700 and Not a Lab Error 8:17 – Part 2, Why I Refused Cholesterol Meds for 7 Years 10:53 – Part 3, The First Plot Twist 12:00 – Proof in my LDL and ApoB, 56% Reductions 18:22 – Part 4, How to Think When the Guidelines Don’t Fit 21:21 – The Final Plot Twist #cholesterol #LDL #hearthealth #statins #cardiology #lipids #healthscience #medicalcase #rareconditions #genetics #familialhypercholesterolemia #preventivemedicine #biomarkers #healthdebate #longevity #metabolichealth #doctorsadvice #patientstory #healthdata #clinicalresearch #case study #evidencebased #nutritiondebate #healthrisk #labresults #healthanalysis #scienceexplained #medicaldiscussion #healthjourney #cholesterollevels #statindebate #heartdisease #riskfactors #biochemistry #healthdecisions #medicalstory #researchreview #healthinsights #patientexperience #sciencecommunication #wellnessscience #healthfacts #doctorpatient #healthquestions #dataoverdogma #clinicalcases #healthperspective #curiositydriven #longtermhealth

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YouTubeApr 30, 2026

This Peptide Reduced Visceral Fat by 15% in Human Trials

For the written breakdown, early access to information like this, and extra nuances, see the associated StayCurious Metabolism Newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/the-peptide-proven-to-reduce-visceral?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true A peptide called tesamorelin has been shown in multiple randomized controlled trials to reduce visceral fat—the type of fat linked to inflammation and cardiometabolic disease. It works by mimicking growth hormone–releasing hormone, stimulating the body’s own growth hormone production. In one study, 6 months of treatment led to a ~15% reduction in visceral fat compared to placebo. For the full mechanisms, limitations, and nuance, watch the long-form breakdown linked above. #VisceralFat #MetabolicHealth #Hormones #GrowthHormone #FatLossScience #ClinicalTrials #StayCurious

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